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KMID : 0378019740170070970
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New Medical Journal
1974 Volume.17 No. 7 p.970 ~ p.978
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Experimental studies of the effects of cortisone on growth development, and calcium contents in bone and teeth
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Abstract
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In order-to observe the effects of cortisone in bone and teeth, the author studied the body weight,´ the growth of mandible, the, length of-tibia, -and calcium contents. _
Experimental groups were divided into 2 groups: the one was the new - born rats which delivered from.´mature- pregnant female rats, administered 50 micrograms of Prednisolone Acetate per grams of body weight, the other was the 3 week old -new born rats, administered 66´ micrograms of Prednisolone Acetate per grams of body weight.
And then the control group were prepared without Prednisolone Acetate in both pregnant adults and new born-rats.
Periodical observation investigation were employed both on the experimental and the control groups from the 1st day to the 7th week -weekly. -
Calcium contents of mandible, tibia, incisor, and molar determined by utilizing the Atomic Absorpt￢ion Spectrophotometer (Perkin-Elmer Co., Model 363) with dry ashing technique.
The following were the results:
1) The body weight in cortisone groups decreased more than the control group.
2) The length of tibia in the control group showed longer than the cortisone groups.
3) The growth of mandible in the cortisone groups showed less than the control group.
4) Calcium contents in tibia, mandible, incisor, and molar decreased in the cortisone group more
than in the control group.
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